| Accession | TIGR02169 |
| Name | SMC_prok_A |
| Function | chromosome segregation protein SMC |
| Gene Symbol | smc |
| Trusted Cutoff | 729.40 |
| Domain Trusted Cutoff | 729.40 |
| Noise Cutoff | 694.65 |
| Domain Noise Cutoff | 694.65 |
| Isology Type | equivalog |
| HMM Length | 1165 |
| Mainrole Category | Cellular processes |
| Subrole Category | Cell division |
| Gene Ontology Term | GO:0005524: ATP binding molecular_function |
| | GO:0007059: chromosome segregation biological_process |
| | GO:0030261: chromosome condensation biological_process |
| Author | Haft DH |
| Entry Date | Apr 22 2004 10:42AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. |
| References | RN [1]
RM 14660695
RT The evolution of SMC proteins: phylogenetic analysis and structural implications.
RA Cobbe N, Heck MM.
RL Mol Biol Evol. 2004 Feb;21(2):332-47 |
| Genome Property | GenProp0201: SMC-ScpA-ScpB complex (HMM) |
