HMM Summary Page: TIGR02191

Functionribonuclease III
Gene Symbolrnc
Trusted Cutoff166.25
Domain Trusted Cutoff166.25
Noise Cutoff165.70
Domain Noise Cutoff165.70
Isology Typeequivalog
EC Number3.1.26.3
HMM Length219
Mainrole CategoryTranscription
Subrole CategoryRNA processing
Gene Ontology TermGO:0004525: ribonuclease III activity molecular_function
GO:0006396: RNA processing biological_process
AuthorHaft DH
Entry DateMay 14 2004 9:25AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of bacterial examples of ribonuclease III. This enzyme cleaves double-stranded rRNA. It is involved in processing ribosomal RNA precursors. It is found even in minimal genones such as Mycoplasma genitalium and Buchnera aphidicola, and in some cases has been shown to be an essential gene. These bacterial proteins contain a double-stranded RNA binding motif (PF00035) and a ribonuclease III domain (PF00636). Eukaryotic homologs tend to be much longer proteins with additional domains, localized to the nucleus, and not included in this family.
ReferencesDR PFAM; PF00035; dsrm DR PFAM; PF00636; Ribonuclease_3 DR HAMAP; MF_00104; 352 of 357
Genome PropertyGenProp0799: bacterial core gene set, exactly 1 per genome (HMM)