| Accession | TIGR02198 |
| Name | rfaE_dom_I |
| Function | bifunctional protein RfaE, domain I |
| Gene Symbol | rfaE |
| Trusted Cutoff | 345.00 |
| Domain Trusted Cutoff | 345.00 |
| Noise Cutoff | 116.90 |
| Domain Noise Cutoff | 116.90 |
| Isology Type | equivalog_domain |
| EC Number | 2.7.1.- |
| HMM Length | 315 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
| Gene Ontology Term | GO:0009244: lipopolysaccharide core region biosynthetic process biological_process |
| | GO:0016773: phosphotransferase activity, alcohol group as acceptor molecular_function |
| Author | Haft DH |
| Entry Date | May 17 2004 1:37PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | RfaE is a protein involved in the biosynthesis of ADP-L-glycero-D-manno-heptose, a precursor for LPS inner core biosynthesis. RfaE is a bifunctional protein in E. coli, and separate proteins in some other genome. The longer, N-terminal domain I (this family) is suggested to act in D-glycero-D-manno-heptose 1-phosphate biosynthesis, while domain II (TIGR02199) adds ADP to yield ADP-D-glycero-D-manno-heptose. |
| References | RM 10629197
RT The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose.
RA Valvano MA, Marolda CL, Bittner M, Glaskin-Clay M, Simon TL, Klena JD.
RL J Bacteriol. 2000 Jan;182(2):488-97.
DR HAMAP; MF_01603; 142 of 148 |
| Genome Property | GenProp0203: LPS inner core biosynthesis, ketodeoxyoctonate and heptose type (HMM) |
