HMM Summary Page: TIGR02199

Functionbifunctional protein RfaE, domain II
Gene SymbolrfaE2
Trusted Cutoff181.50
Domain Trusted Cutoff181.50
Noise Cutoff91.55
Domain Noise Cutoff91.55
Isology Typeequivalog_domain
EC Number2.7.7.-
HMM Length144
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0009244: lipopolysaccharide core region biosynthetic process biological_process
GO:0016779: nucleotidyltransferase activity molecular_function
AuthorHaft DH
Entry DateMay 17 2004 1:42PM
Last ModifiedFeb 14 2011 3:27PM
CommentRfaE is a protein involved in the biosynthesis of ADP-L-glycero-D-manno-heptose, a precursor for LPS inner core biosynthesis. RfaE is a bifunctional protein in E. coli, and separate proteins in some other genome. Domain I (TIGR02198) is suggested to act in D-glycero-D-manno-heptose 1-phosphate biosynthesis, while domain II (this family) adds ADP to yield ADP-D-glycero-D-manno-heptose.
ReferencesRM 10629197 RT The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose. RA Valvano MA, Marolda CL, Bittner M, Glaskin-Clay M, Simon TL, Klena JD. RL J Bacteriol. 2000 Jan;182(2):488-97. DR HAMAP; MF_01603; 145 of 148
Genome PropertyGenProp0203: LPS inner core biosynthesis, ketodeoxyoctonate and heptose type (HMM)