|Function||lipoprotein releasing system, ATP-binding protein|
|Domain Trusted Cutoff||307.75|
|Domain Noise Cutoff||284.45|
|Mainrole Category||Protein fate|
|Subrole Category||Protein and peptide secretion and trafficking|
|Gene Ontology Term||GO:0005524: ATP binding molecular_function|
| ||GO:0042953: lipoprotein transport biological_process|
| ||GO:0042954: lipoprotein transporter activity molecular_function|
| ||GO:0043190: ATP-binding cassette (ABC) transporter complex cellular_component|
|Entry Date||May 26 2004 4:06PM|
|Last Modified||Dec 21 2011 12:17PM|
|Comment||This model represents LolD, a member of the ABC transporter family (PF00005). LolD is involved in localization of lipoproteins in some bacteria. It works with a transmembrane protein LolC, which in some species is a paralogous pair LolC and LolE. Depending on whether the residue immediately following the new, modified N-terminal Cys residue, the nascent lipoprotein may be carried further by LolA and LolB to the outer membrane, or remain at the inner membrane. The top scoring proteins excluded by this model include homologs from the archaeal genus Methanosarcina.|
|References||DR PF00005; ABC_tran
RT A mutation in the membrane subunit of an ABC transporter LolCDE complex causing outer membrane localization of lipoproteins against their inner membrane-specific signals.
RA Narita S, Kanamaru K, Matsuyama S, Tokuda H.
RL Mol Microbiol. 2003 Jul;49(1):167-77.
DR HAMAP; MF_01708; 96 of 186|
|Genome Property||GenProp0207: lipoprotein localization system lolABCDE (HMM)|
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