Accession | TIGR02254 |
Name | YjjG/YfnB |
Function | noncanonical pyrimidine nucleotidase, YjjG family |
Trusted Cutoff | 159.90 |
Domain Trusted Cutoff | 159.90 |
Noise Cutoff | 152.10 |
Domain Noise Cutoff | 152.10 |
Isology Type | equivalog |
EC Number | 3.1.3.5 |
HMM Length | 223 |
Author | Selengut J, Haft DH |
Entry Date | Aug 3 2004 11:35AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HAD superfamily includes including YjjG from E. coli and YfnB from B. subtilis. YjjG has been shown to act as a house-cleaning enzyme, cleaving nucleotides with non-canonical nucleotide bases. This family is a member of the haloacid dehalogenase (HAD) superfamily of hydrolases which are characterized by three conserved sequence motifs [2]. By virtue of an alpha helical domain in-between the first and second conserved motif, this family is a member of subfamily IA (TIGR01549). |
References | RN [1]
RM PMID:17286574
RT The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.
RA Titz B, Hauser R, Engelbrecher A, Uetz P
RL FEMS Microbiol Lett. 2007 May;270(1):49-57.
RN [2]
RM PMID: 7966317
RT Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search.
RA Koonin EV, Tatusov RL.
RL J Mol Biol 1994 Nov 18;244(1):125-32 |