HMM Summary Page: TIGR02279

Function3-hydroxyacyl-CoA dehydrogenase PaaC
Gene SymbolpaaC
Trusted Cutoff669.40
Domain Trusted Cutoff669.40
Noise Cutoff593.65
Domain Noise Cutoff593.65
Isology Typeequivalog
EC Number1.1.1.-
HMM Length503
AuthorSelengut J
Entry DateAug 31 2004 12:56PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis 3-hydroxyacyl-CoA dehydrogenase is involved in the degradation of phenylacetic acid, presumably in steps following the opening of the phenyl ring [1]. The sequences included in this model are all found in aparrent operons with other related genes such as paaA, paaB, paaD, paaE, paaF and paaN [2]. Some genomes contain these other genes without an apparent paaC in the same operon - possibly in these cases a different dehydrogenase involved in fatty acid degradation may fill in the needed activity. This enzyme has domains which are members of the PF02737 and PF00725 families.
ReferencesRN [1] RM PMID: 9748275 RT Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway. RA Ferrandez A, Minambres B, Garcia B, Olivera ER, Luengo JM, Garcia JL, Diaz E. RL J Biol Chem. 1998 Oct 2;273(40):25974-86. RN [2] RM PMID: 11260461 RT The phenylacetyl-CoA catabolon: a complex catabolic unit with broad biotechnological applications. RA Luengo JM, Garcia JL, Olivera ER. RL Mol Microbiol. 2001 Mar;39(6):1434-42.
Genome PropertyGenProp0210: phenylacetic acid catabolism (HMM)