HMM Summary Page: TIGR02280

Functionphenylacetate degradation probable enoyl-CoA hydratase PaaB
Gene SymbolpaaB
Trusted Cutoff345.15
Domain Trusted Cutoff345.15
Noise Cutoff303.40
Domain Noise Cutoff303.40
Isology Typeequivalog
EC Number4.2.1.17
HMM Length256
Gene Ontology TermGO:0004300: enoyl-CoA hydratase activity molecular_function
GO:0010124: phenylacetate catabolic process biological_process
AuthorSelengut J
Entry DateAug 31 2004 2:49PM
Last ModifiedMar 1 2011 11:50AM
CommentThis family of proteins are found within apparent operons for the degradation of phenylacetic acid [1]. These proteins contain the enoyl-CoA hydratase domain as detected by PF00378. This activity is consistent with current hypotheses for the degradation pathway [2] which involve the ligation of phenylacetate with coenzyme A (paaF), hydroxylation (paaGHIJK), ring-opening (paaN) and degradation of the resulting fatty acid-like compound to a Krebs cycle intermediate (paaABCDE).
ReferencesRN [1] RM PMID: 11260461 RT The phenylacetyl-CoA catabolon: a complex catabolic unit with broad biotechnological applications. RA Luengo JM, Garcia JL, Olivera ER. RL Mol Microbiol. 2001 Mar;39(6):1434-42. RN [2] RM PMID: 9748275 RT Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway. RA Ferrandez A, Minambres B, Garcia B, Olivera ER, Luengo JM, Garcia JL, Diaz E. RL J Biol Chem. 1998 Oct 2;273(40):25974-86.
Genome PropertyGenProp0210: phenylacetic acid catabolism (HMM)