|Domain Trusted Cutoff||321.40|
|Domain Noise Cutoff||264.70|
|Entry Date||Sep 9 2004 3:29PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This enzyme catalyzes the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate. 4-hydroxyphenylacetate arises from the degradation of tyrosine. The substrate, 3,4-dihydroxyphenylacetate (homoprotocatechuate) arises from the action of a hydroxylase on 4-hydroxyphenylacetate. The aromatic ring is opened by this dioxygenase exo to the 3,4-diol resulting in 2-hydroxy-5-carboxymethylmuconate semialdehyde.
The enzyme from Bacillus brevis contains manganese .|
RM PMID: 6270137
RT 3,4-Dihydroxyphenylacetate 2,3-dioxygenase. A manganese(II) dioxygenase from Bacillus brevis.
RA Que L Jr, Widom J, Crawford RL.
RL J Biol Chem. 1981 Nov 10;256(21):10941-4.|
|Genome Property||GenProp0231: 4-hydroxyphenylacetate degradation (HMM)|
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