|Function||4-hydroxyphenylacetate 3-monooxygenase, reductase component|
|Domain Trusted Cutoff||205.95|
|Domain Noise Cutoff||178.90|
|Gene Ontology Term||GO:0018660: 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity molecular_function|
|Entry Date||Sep 10 2004 9:33AM|
|Last Modified||May 22 2012 12:18PM|
|Comment||This model identifies the reductase component (HpaC) of 4-hydroxyphenylacetate 3-monooxygenase . This enzyme catalyzes the first step (hydroxylation at the 3-position) in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate. 4-hydroxyphenylacetate arises from the degradation of tyrosine.
These reductases catalyze the reduction of free flavins by NADPH. The flavin is then utilized by the large subunit of the monooxygenase.|
RM PMID: 8077235
RT Molecular characterization of 4-hydroxyphenylacetate 3-hydroxylase of Escherichia coli. A two-protein component enzyme.
RA Prieto MA, Garcia JL.
RL J Biol Chem. 1994 Sep 9;269(36):22823-9.|
|Genome Property||GenProp0231: 4-hydroxyphenylacetate degradation (HMM)|
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