HMM Summary Page: TIGR02296

Function4-hydroxyphenylacetate 3-monooxygenase, reductase component
Gene SymbolhpaC
Trusted Cutoff205.95
Domain Trusted Cutoff205.95
Noise Cutoff178.90
Domain Noise Cutoff178.90
Isology Typeequivalog
EC Number1.14.14.9
HMM Length154
Gene Ontology TermGO:0018660: 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity molecular_function
AuthorSelengut J
Entry DateSep 10 2004 9:33AM
Last ModifiedMay 22 2012 12:18PM
CommentThis model identifies the reductase component (HpaC) of 4-hydroxyphenylacetate 3-monooxygenase [1]. This enzyme catalyzes the first step (hydroxylation at the 3-position) in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate. 4-hydroxyphenylacetate arises from the degradation of tyrosine. These reductases catalyze the reduction of free flavins by NADPH. The flavin is then utilized by the large subunit of the monooxygenase.
ReferencesRN [1] RM PMID: 8077235 RT Molecular characterization of 4-hydroxyphenylacetate 3-hydroxylase of Escherichia coli. A two-protein component enzyme. RA Prieto MA, Garcia JL. RL J Biol Chem. 1994 Sep 9;269(36):22823-9.
Genome PropertyGenProp0231: 4-hydroxyphenylacetate degradation (HMM)