Accession | TIGR02303 |
Name | HpaG-C-term |
Function | 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit |
Gene Symbol | hpaG |
Trusted Cutoff | 276.40 |
Domain Trusted Cutoff | 276.40 |
Noise Cutoff | 242.80 |
Domain Noise Cutoff | 242.80 |
Isology Type | equivalog_domain |
EC Number | 4.1.1.68 5.3.3.10 |
HMM Length | 245 |
Author | Selengut J |
Entry Date | Sep 20 2004 3:37PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This model represents one of two subunits/domains of the bifunctional isomerase/decarboxylase involved in 4-hydroxyphenylacetate degradation [1]. In E. coli and some other species this enzyme is encoded by a single polypeptide containing both this domain and the closely related N-terminal domain (TIGR02305). In other species such as Pasteurella multocida these domains are found as two separate proteins (usually as tandem genes). Together, these domains carry out the decarboxylation of 5-oxopent-3-ene-1,2,5-tricarboxylic acid (OPET) to 2-hydroxy-2,4-diene-1,7-dioate (HHDD) and the subsequent isomerization to 2-oxohept-3-ene-1,7-dioate (OHED). |
References | RN [1]
RM PMID: 11863436
RT The crystal structure of HpcE, a bifunctional decarboxylase/isomerase with a multifunctional fold.
RA Tame JR, Namba K, Dodson EJ, Roper DI.
RL Biochemistry. 2002 Mar 5;41(9):2982-9. |
Genome Property | GenProp0231: 4-hydroxyphenylacetate degradation (HMM) |