HMM Summary Page: TIGR02317
Accession | TIGR02317 |
Name | prpB |
Function | methylisocitrate lyase |
Gene Symbol | prpB |
Trusted Cutoff | 354.40 |
Domain Trusted Cutoff | 354.40 |
Noise Cutoff | 318.80 |
Domain Noise Cutoff | 318.80 |
Isology Type | equivalog |
EC Number | 4.1.3.30 |
HMM Length | 285 |
Gene Ontology Term | GO:0019629: propionate catabolic process, 2-methylcitrate cycle biological_process |
GO:0046421: methylisocitrate lyase activity molecular_function | |
Author | Haft DH |
Entry Date | Sep 27 2004 2:14PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Members of this family are methylisocitrate lyase, also called (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase. This enzyme acts in propionate metabolism. It cleaves a carbon-carbon bond to convert 2-methylisocitrate to pyruvate plus succinate. Some members of this family have been annotated, incorrectly it seems, as the related protein carboxyphosphoenolpyruvate phosphomutase, which is involved in synthesizing the antibiotic bialaphos in Streptomyces hygroscopicus. |
Genome Property | GenProp0240: propionyl-CoA catabolism via methylcitric acid (HMM) |