HMM Summary Page: TIGR02326

Function2-aminoethylphosphonate--pyruvate transaminase
Gene SymbolphnW
Trusted Cutoff400.80
Domain Trusted Cutoff400.80
Noise Cutoff339.35
Domain Noise Cutoff339.35
Isology Typeequivalog
EC Number2.6.1.37
HMM Length363
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryPhosphorus compounds
AuthorHaft DH
Entry DateSep 29 2004 2:21PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are 2-aminoethylphosphonate--pyruvate transaminase. This enzyme acts on the most common type of naturally occurring phosphonate. It interconverts 2-aminoethylphosphonate plus pyruvate with 2-phosphonoacetaldehyde plus alanine. The enzyme phosphonoacetaldehyde hydrolase (EC, usually encoded by an adjacent gene, then cleaves the C-P bond of phosphonoacetaldehyde, adding water to yield acetaldehyde plus inorganic phosphate. Species with this pathway generally have an identified phosphonate ABC transporter but do not also have the multisubunit C-P lysase complex as found in Escherichia coli.
References DR HAMAP; MF_01376; 56 of 56
Genome PropertyGenProp0238: 2-aminoethylphosphonate catabolism to acetaldehyde (HMM)
GenProp0713: 2-aminoethylphosphonate catabolism via phosphonoacetate (HMM)
GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (SUBFAM-EX)