|Domain Trusted Cutoff||458.00|
|Domain Noise Cutoff||330.70|
|Gene Ontology Term||GO:0019629: propionate catabolic process, 2-methylcitrate cycle biological_process|
| ||GO:0047547: 2-methylcitrate dehydratase activity molecular_function|
|Entry Date||Sep 30 2004 1:41PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Members of this family are bacterial proteins known or predicted to act as 2-methylcitrate dehydratase, an enzyme involved in the methylcitrate cycle of propionate catabolism. A related clade of archaeal proteins that may or may not be functionally equivalent is reserved for a future model and is excluded from this family. The PrpD enzyme of E. coli is responsible for the minor aconitase activity (AcnC) not accounted for by AcnA and AcnB.|
RT Oxidation of propionate to pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase.
RA Brock M, Maerker C, Schutz A, Volker U, Buckel W.
RL Eur J Biochem. 2002 Dec;269(24):6184-94.
RT AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates.
RA Blank L, Green J, Guest JR.
RL Microbiology. 2002 Jan;148(Pt 1):133-46.|
|Genome Property||GenProp0240: propionyl-CoA catabolism via methylcitric acid (HMM)|
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