HMM Summary Page: TIGR02332

Function4-hydroxyphenylacetate permease
Gene SymbolhpaX
Trusted Cutoff615.40
Domain Trusted Cutoff615.40
Noise Cutoff527.90
Domain Noise Cutoff527.90
Isology Typeequivalog
HMM Length412
AuthorSelengut J, Haft DH
Entry DateOct 1 2004 9:44AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein is a part of the Major Facilitator Superfamily (Pfam family PF07690). Member of this family are found in a number of proteobacterial genomes, but only in the context of having genes for 4-hydroxyphenylacetate (4-HPA) degradation. The protein is characterized by Prieto, et al. (PMID:9315705) as 4-hydroxyphenylacetate permease in E. coli, where 3-HPA and 3,4-dihydroxyphenylacetate are shown to competitively inhibit 4-HPA transport and therefore also interact specificially.
ReferencesRN [1] RM 9315705 RT Identification of the 4-hydroxyphenylacetate transport gene of Escherichia coli W: construction of a highly sensitive cellular biosensor. RA Prieto MA, Garcia JL. RL FEBS Lett. 1997 Sep 8;414(2):293-7.
Genome PropertyGenProp0231: 4-hydroxyphenylacetate degradation (HMM)