|Function||2-methylisocitrate dehydratase, Fe/S-dependent|
|Domain Trusted Cutoff||1419.85|
|Domain Noise Cutoff||1137.30|
|Gene Ontology Term||GO:0019629: propionate catabolic process, 2-methylcitrate cycle biological_process|
| ||GO:0047456: 2-methylisocitrate dehydratase activity molecular_function|
|Entry Date||Oct 1 2004 10:30AM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Members of this family appear in an operon for the degradation of propionyl-CoA via 2-methylcitrate. This family is homologous to aconitases A and B and appears to act the part as 2-methylisocitrate dehydratase, the enzyme after PrpD and before PrpB. In Escherichia coli, which lacks a member of this family, 2-methylisocitrate dehydratase activity was traced to aconitase B (TIGR00117) (PMID:12473114).|
RT The acnD genes of Shewenella oneidensis and Vibrio cholerae encode a new Fe/S-dependent 2-methylcitrate dehydratase enzyme that requires prpF function in vivo.
RA Grimek TL, Escalante-Semerena JC.
RL J Bacteriol. 2004 Jan;186(2):454-62.|
|Genome Property||GenProp0240: propionyl-CoA catabolism via methylcitric acid (HMM)|
© J. Craig Venter Institute | Privacy Statement | Data Disclaimer