HMM Summary Page: TIGR02333

Function2-methylisocitrate dehydratase, Fe/S-dependent
Gene SymbolacnD
Trusted Cutoff1419.85
Domain Trusted Cutoff1419.85
Noise Cutoff1137.30
Domain Noise Cutoff1137.30
Isology Typeequivalog
EC Number4.2.1.99
HMM Length858
Gene Ontology TermGO:0019629: propionate catabolic process, 2-methylcitrate cycle biological_process
GO:0047456: 2-methylisocitrate dehydratase activity molecular_function
AuthorHaft DH
Entry DateOct 1 2004 10:30AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family appear in an operon for the degradation of propionyl-CoA via 2-methylcitrate. This family is homologous to aconitases A and B and appears to act the part as 2-methylisocitrate dehydratase, the enzyme after PrpD and before PrpB. In Escherichia coli, which lacks a member of this family, 2-methylisocitrate dehydratase activity was traced to aconitase B (TIGR00117) (PMID:12473114).
ReferencesRN [1] RM 14702315 RT The acnD genes of Shewenella oneidensis and Vibrio cholerae encode a new Fe/S-dependent 2-methylcitrate dehydratase enzyme that requires prpF function in vivo. RA Grimek TL, Escalante-Semerena JC. RL J Bacteriol. 2004 Jan;186(2):454-62.
Genome PropertyGenProp0240: propionyl-CoA catabolism via methylcitric acid (HMM)