| Accession | TIGR02334 |
| Name | prpF |
| Function | probable AcnD-accessory protein PrpF |
| Gene Symbol | prpF |
| Trusted Cutoff | 440.55 |
| Domain Trusted Cutoff | 440.55 |
| Noise Cutoff | 415.90 |
| Domain Noise Cutoff | 415.90 |
| Isology Type | equivalog |
| HMM Length | 390 |
| Gene Ontology Term | GO:0019629: propionate catabolic process, 2-methylcitrate cycle biological_process |
| Author | Haft DH |
| Entry Date | Oct 1 2004 12:45PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | The 2-methylcitrate cycle is one of at least five degradation pathways for propionate via propionyl-CoA. Degradation of propionate toward pyruvate consumes oxaloacetate and releases succinate. Oxidation of succinate back into oxaloacetate by the TCA cycle makes the 2-methylcitrate pathway a cycle. This family consists of PrpF, an incompletely characterized protein that appears to be an essential accessory protein for the Fe/S-dependent 2-methylisocitrate dehydratase AcnD (TIGR02333). This protein is related to but distinct from FldA (part of Pfam family PF04303), a putative fluorene degradation protein of Sphingomonas sp. LB126. |
| References | DR PFAM; PF04303; DUF453 |
| Genome Property | GenProp0240: propionyl-CoA catabolism via methylcitric acid (HMM) |
