HMM Summary Page: TIGR02351

Functionthiazole biosynthesis protein ThiH
Gene SymbolthiH
Trusted Cutoff377.80
Domain Trusted Cutoff377.80
Noise Cutoff165.85
Domain Noise Cutoff165.85
Isology Typeequivalog
HMM Length366
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryThiamine
Gene Ontology TermGO:0003824: catalytic activity molecular_function
GO:0009228: thiamine biosynthetic process biological_process
AuthorHaft DH
Entry DateOct 11 2004 1:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers this protein family are the ThiH protein of thiamine biosynthesis, a homolog of the BioB protein of biotin biosynthesis. Genes for the this protein generally are found in operons with other thiamin biosynthesis genes.
ReferencesRN [1] RM 14757766 RT Thiamine biosynthesis in Escherichia coli: in vitro reconstitution of the thiazole synthase activity. RA Leonardi R, Roach PL. RL J Biol Chem. 2004 Apr 23;279(17):17054-62.
Genome PropertyGenProp0250: thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly (HMM)