|Function||glycine oxidase ThiO|
|Domain Trusted Cutoff||250.80|
|Domain Noise Cutoff||222.75|
|Mainrole Category||Biosynthesis of cofactors, prosthetic groups, and carriers|
|Gene Ontology Term||GO:0016647: oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor molecular_function|
|Entry Date||Oct 12 2004 5:23PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This family consists of the homotetrameric, FAD-dependent glycine oxidase ThiO, from species such as Bacillus subtilis that use glycine in thiamine biosynthesis. In general, members of this family will not be found in species such as E. coli that instead use tyrosine and the ThiH protein.|
RT Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis.
RA Settembre EC, Dorrestein PC, Park JH, Augustine AM, Begley TP, Ealick SE.
RL Biochemistry. 2003 Mar 18;42(10):2971-81.|
|Genome Property||GenProp0250: thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly (HMM)|
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