|Function||thiazole biosynthesis adenylyltransferase ThiF|
|Domain Trusted Cutoff||275.25|
|Domain Noise Cutoff||269.75|
|Mainrole Category||Biosynthesis of cofactors, prosthetic groups, and carriers|
|Gene Ontology Term||GO:0009228: thiamine biosynthetic process biological_process|
| ||GO:0016779: nucleotidyltransferase activity molecular_function|
|Entry Date||Oct 14 2004 12:03PM|
|Last Modified||Dec 19 2011 11:31AM|
|Comment||Members of the HesA/MoeB/ThiF family of proteins (PF00899) include a number of members encoded in the midst of thiamine biosynthetic operons. This mix of known and putative ThiF proteins shows a deep split in phylogenetic trees, with the Escherichia. coli ThiF and the E. coli MoeB proteins seemingly more closely related than E. coli ThiF and Campylobacter (for example) ThiF. This model represents the more widely distributed clade of ThiF proteins such found in E. coli.|
|References||DR PFAM; PF00899; ThiF family
RT Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
RA Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
RL Biochemistry. 2003 Oct 28;42(42):12430-8.|
|Genome Property||GenProp0250: thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly (HMM)|
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