HMM Summary Page: TIGR02356

Functionthiazole biosynthesis adenylyltransferase ThiF
Gene SymbolthiF
Trusted Cutoff275.25
Domain Trusted Cutoff275.25
Noise Cutoff269.75
Domain Noise Cutoff269.75
Isology Typeequivalog
EC Number2.7.7.73
HMM Length203
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryThiamine
Gene Ontology TermGO:0009228: thiamine biosynthetic process biological_process
GO:0016779: nucleotidyltransferase activity molecular_function
AuthorHaft DH
Entry DateOct 14 2004 12:03PM
Last ModifiedDec 19 2011 11:31AM
CommentMembers of the HesA/MoeB/ThiF family of proteins (PF00899) include a number of members encoded in the midst of thiamine biosynthetic operons. This mix of known and putative ThiF proteins shows a deep split in phylogenetic trees, with the Escherichia. coli ThiF and the E. coli MoeB proteins seemingly more closely related than E. coli ThiF and Campylobacter (for example) ThiF. This model represents the more widely distributed clade of ThiF proteins such found in E. coli.
ReferencesDR PFAM; PF00899; ThiF family RM 14567704 RT Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1). RA Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP. RL Biochemistry. 2003 Oct 28;42(42):12430-8.
Genome PropertyGenProp0250: thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly (HMM)