| Accession | TIGR02380 |
| Name | ECA_wecA |
| Function | undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase |
| Gene Symbol | wecA |
| Trusted Cutoff | 326.05 |
| Domain Trusted Cutoff | 326.05 |
| Noise Cutoff | 191.90 |
| Domain Noise Cutoff | 191.90 |
| Isology Type | equivalog |
| EC Number | 2.7.8.33 |
| HMM Length | 346 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
| Gene Ontology Term | GO:0009246: enterobacterial common antigen biosynthetic process biological_process |
| | GO:0016780: phosphotransferase activity, for other substituted phosphate groups molecular_function |
| Author | Haft DH |
| Entry Date | Nov 19 2004 5:20PM |
| Last Modified | Dec 12 2011 11:06PM |
| Comment | Members of this family are the WecA enzyme of enterobacterial common antigen biosynthesis, undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase. This family represents one narrow clade, and closely related sequences outside this clade may represent enzymes that catalyze the same specific reaction, but in the context of different pathways. A His-rich motif in a cytosolic loop of this integral membrane protein, shown critical to enzymatic activity for WecA (see ref [1]) is variously present or absent in the clade that includes Bacillus subtilis TagO teichoic acid biosynthesis enzyme, which may catalyze the same reaction as WecA. |
| References | RN [1]
RM 11700352
RT Conserved amino acid residues found in a predicted cytosolic domain of the lipopolysaccharide biosynthetic protein WecA are implicated in the recognition of UDP-N-acetylglucosamine.
RA Amer AO, Valvano MA.
RL Microbiology. 2001 Nov;147(Pt 11):3015-25. |
| Genome Property | GenProp0970: biosynthesis of Und-PP-GlcNAc (HMM) |
