|Function||undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase|
|Domain Trusted Cutoff||326.05|
|Domain Noise Cutoff||191.90|
|Mainrole Category||Cell envelope|
|Subrole Category||Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides|
|Gene Ontology Term||GO:0009246: enterobacterial common antigen biosynthetic process biological_process|
| ||GO:0016780: phosphotransferase activity, for other substituted phosphate groups molecular_function|
|Entry Date||Nov 19 2004 5:20PM|
|Last Modified||Dec 12 2011 11:06PM|
|Comment||Members of this family are the WecA enzyme of enterobacterial common antigen biosynthesis, undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase. This family represents one narrow clade, and closely related sequences outside this clade may represent enzymes that catalyze the same specific reaction, but in the context of different pathways. A His-rich motif in a cytosolic loop of this integral membrane protein, shown critical to enzymatic activity for WecA (see ref ) is variously present or absent in the clade that includes Bacillus subtilis TagO teichoic acid biosynthesis enzyme, which may catalyze the same reaction as WecA.|
RT Conserved amino acid residues found in a predicted cytosolic domain of the lipopolysaccharide biosynthetic protein WecA are implicated in the recognition of UDP-N-acetylglucosamine.
RA Amer AO, Valvano MA.
RL Microbiology. 2001 Nov;147(Pt 11):3015-25.|
|Genome Property||GenProp0970: biosynthesis of Und-PP-GlcNAc (HMM)|
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