HMM Summary Page: TIGR02380

Functionundecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase
Gene SymbolwecA
Trusted Cutoff326.05
Domain Trusted Cutoff326.05
Noise Cutoff191.90
Domain Noise Cutoff191.90
Isology Typeequivalog
EC Number2.7.8.33
HMM Length346
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0009246: enterobacterial common antigen biosynthetic process biological_process
GO:0016780: phosphotransferase activity, for other substituted phosphate groups molecular_function
AuthorHaft DH
Entry DateNov 19 2004 5:20PM
Last ModifiedDec 12 2011 11:06PM
CommentMembers of this family are the WecA enzyme of enterobacterial common antigen biosynthesis, undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase. This family represents one narrow clade, and closely related sequences outside this clade may represent enzymes that catalyze the same specific reaction, but in the context of different pathways. A His-rich motif in a cytosolic loop of this integral membrane protein, shown critical to enzymatic activity for WecA (see ref [1]) is variously present or absent in the clade that includes Bacillus subtilis TagO teichoic acid biosynthesis enzyme, which may catalyze the same reaction as WecA.
ReferencesRN [1] RM 11700352 RT Conserved amino acid residues found in a predicted cytosolic domain of the lipopolysaccharide biosynthetic protein WecA are implicated in the recognition of UDP-N-acetylglucosamine. RA Amer AO, Valvano MA. RL Microbiology. 2001 Nov;147(Pt 11):3015-25.
Genome PropertyGenProp0970: biosynthesis of Und-PP-GlcNAc (HMM)