HMM Summary Page: TIGR02427

Function3-oxoadipate enol-lactonase
Gene SymbolpcaD
Trusted Cutoff255.85
Domain Trusted Cutoff255.85
Noise Cutoff179.40
Domain Noise Cutoff179.40
Isology Typeequivalog
EC Number3.1.1.24
HMM Length251
Mainrole CategoryEnergy metabolism
Subrole CategoryOther
Gene Ontology TermGO:0042952: beta-ketoadipate pathway biological_process
GO:0047570: 3-oxoadipate enol-lactonase activity molecular_function
AuthorHaft DH
Entry DateJan 13 2005 10:03AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate.
ReferencesRN [1] RM 15006791 RT Diverse organization of genes of the beta-ketoadipate pathway in members of the marine Roseobacter lineage. RA Buchan A, Neidle EL, Moran MA. RL Appl Environ Microbiol. 2004 Mar;70(3):1658-68.
Genome PropertyGenProp0273: protocatechuate degradation to beta-ketoadipate (HMM)
GenProp0711: catechol ortho-cleavage upper pathway (HMM)