HMM Summary Page: TIGR02433

AccessionTIGR02433
Namelysidine_TilS_C
FunctiontRNA(Ile)-lysidine synthetase, C-terminal domain
Gene SymboltilS
Trusted Cutoff20.20
Domain Trusted Cutoff20.20
Noise Cutoff18.95
Domain Noise Cutoff18.95
Isology Typeequivalog_domain
EC Number6.-.-.-
HMM Length47
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0006400: tRNA modification biological_process
GO:0006400: tRNA modification biological_process
GO:0016879: ligase activity, forming carbon-nitrogen bonds molecular_function
GO:0016879: ligase activity, forming carbon-nitrogen bonds molecular_function
AuthorHaft DH
Entry DateJan 18 2005 12:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentTIGRFAMs model TIGR02432 describes the family of the N-terminal domain of tRNA(Ile)-lysidine synthetase. This family (TIGR02433) describes a small C-terminal domain of about 50 residues present in about half the members of family TIGR02432,and in no other protein. Characterized examples of tRNA(Ile)-lysidine synthetase from E. coli and Bacillus subtilis both contain this domain.
ReferencesDR PFAM; PF01171; ATP_bind_3; PP-loop family RN [1] RM 14527414 RT An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA. RA Soma A, Ikeuchi Y, Kanemasa S, Kobayashi K, Ogasawara N, Ote T, Kato J, Watanabe K, Sekine Y, Suzuki T. RL Mol Cell. 2003 Sep;12(3):689-98. RN [2] RM 3132458 RT A novel lysine-substituted nucleoside in the first position of the anticodon of minor isoleucine tRNA from Escherichia coli. RA Muramatsu T, Yokoyama S, Horie N, Matsuda A, Ueda T, Yamaizumi Z, Kuchino Y, Nishimura S, Miyazawa T. RL J Biol Chem. 1988 Jul 5;263(19):9261-7. RN [3] RM 15044829 RT A global approach to identify novel broad-spectrum antibacterial targets among proteins of unknown function. RA Zalacain M, Biswas S, Ingraham KA, Ambrad J, Bryant A, Chalker AF, Iordanescu S, Fan J, Fan F, Lunsford RD, O'Dwyer K, Palmer LM, So C, Sylvester D, Volker C, Warren P, McDevitt D, Brown JR, Holmes DJ, Burnham MK. RL J Mol Microbiol Biotechnol. 2003;6(2):109-26. DR HAMAP; MF_01161; 120 of 240