HMM Summary Page: TIGR02434

Functionprecorrin-6A synthase (deacetylating)
Gene SymbolcobF
Trusted Cutoff195.80
Domain Trusted Cutoff195.80
Noise Cutoff119.45
Domain Noise Cutoff119.45
Isology Typeequivalog
EC Number2.1.1.152
HMM Length250
AuthorSelengut J
Entry DateJan 21 2005 10:19AM
Last ModifiedFeb 14 2011 3:27PM
CommentIn the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC, C-11 (CobM; EC and C-1 (CobF; EC of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively [1]. This model identifies CobF in High GC gram positive, alphaproteobacteria and pseudomonas-related species.
ReferencesRN [1] RT Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans. RA Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F. RL J Bacteriol. 1993 Nov;175(22):7430-40.
Genome PropertyGenProp0113: cobyrinic acid diamide biosynthesis, aerobic pathway (HMM)