| Accession | TIGR02435 |
| Name | CobG |
| Function | precorrin-3B synthase |
| Gene Symbol | cobG |
| Trusted Cutoff | 234.80 |
| Domain Trusted Cutoff | 234.80 |
| Noise Cutoff | 222.65 |
| Domain Noise Cutoff | 222.65 |
| Isology Type | equivalog |
| EC Number | 1.14.13.83 |
| HMM Length | 388 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Heme, porphyrin, and cobalamin |
| Gene Ontology Term | GO:0016709: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen molecular_function |
| | GO:0019250: aerobic cobalamin biosynthetic process biological_process |
| Author | Selengut J |
| Entry Date | Jan 21 2005 2:41PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | An iron-sulfur protein. An oxygen atom from dioxygen is incorporated into the macrocycle at C-20. In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively. |
| Genome Property | GenProp0113: cobyrinic acid diamide biosynthesis, aerobic pathway (HMM) |
