HMM Summary Page: TIGR02435

Functionprecorrin-3B synthase
Gene SymbolcobG
Trusted Cutoff234.80
Domain Trusted Cutoff234.80
Noise Cutoff222.65
Domain Noise Cutoff222.65
Isology Typeequivalog
EC Number1.14.13.83
HMM Length388
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryHeme, porphyrin, and cobalamin
Gene Ontology TermGO:0016709: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen molecular_function
GO:0019250: aerobic cobalamin biosynthetic process biological_process
AuthorSelengut J
Entry DateJan 21 2005 2:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentAn iron-sulfur protein. An oxygen atom from dioxygen is incorporated into the macrocycle at C-20. In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC, C-11 (CobM; EC and C-1 (CobF; EC of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively.
Genome PropertyGenProp0113: cobyrinic acid diamide biosynthesis, aerobic pathway (HMM)