HMM Summary Page: TIGR02437

Functionfatty oxidation complex, alpha subunit FadB
Gene SymbolfadB
Trusted Cutoff933.55
Domain Trusted Cutoff933.55
Noise Cutoff726.70
Domain Noise Cutoff726.70
Isology Typeequivalog
EC Number4.2.1.17
HMM Length714
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryDegradation
Gene Ontology TermGO:0003857: 3-hydroxyacyl-CoA dehydrogenase activity molecular_function
GO:0004165: dodecenoyl-CoA delta-isomerase activity molecular_function
GO:0004300: enoyl-CoA hydratase activity molecular_function
GO:0008692: 3-hydroxybutyryl-CoA epimerase activity molecular_function
GO:0009062: fatty acid catabolic process biological_process
AuthorRosovitz MJ, Haft DH
Entry DateJan 25 2005 3:23PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers represent alpha subunit of multifunctional enzyme complex of the fatty acid degradation cycle. Activities include: enoyl-CoA hydratase (EC, dodecenoyl-CoA delta-isomerase activity (EC, 3-hydroxyacyl-CoA dehydrogenase (EC, 3-hydroxybutyryl-CoA epimerase (EC A representative is E. coli FadB (SP:P21177). This model excludes the FadJ family represented by SP:P77399.
ReferencesRN [1] RM 1699931 RT Primary sequence of the Escherichia coli fadBA operon, encoding the fatty acid-oxidizing multienzyme complex, indicates a high degree of homology to eucaryotic enzymes. RA DiRusso CC. RL J Bacteriol. 1990 Nov;172(11):6459-68. DR HAMAP; MF_01621; 78 of 80