| Accession | TIGR02441 |
| Name | fa_ox_alpha_mit |
| Function | fatty acid oxidation complex, alpha subunit, mitochondrial |
| Trusted Cutoff | 964.65 |
| Domain Trusted Cutoff | 964.65 |
| Noise Cutoff | 771.75 |
| Domain Noise Cutoff | 771.75 |
| Isology Type | equivalog |
| EC Number | 4.2.1.17 1.1.1.35 |
| HMM Length | 737 |
| Gene Ontology Term | GO:0003857: 3-hydroxyacyl-CoA dehydrogenase activity molecular_function |
| | GO:0004300: enoyl-CoA hydratase activity molecular_function |
| | GO:0006635: fatty acid beta-oxidation biological_process |
| | GO:0016507: mitochondrial fatty acid beta-oxidation multienzyme complex cellular_component |
| Author | Rosovitz MJ, Haft DH |
| Entry Date | Jan 26 2005 12:53PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) & 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16). |
| References | RN [1]
RM 8135828
RT Structural analysis of cDNAs for subunits of human mitochondrial fatty acid beta-oxidation trifunctional protein.
RA Kamijo T, Aoyama T, Komiyama A, Hashimoto T.
RL Biochem Biophys Res Commun. 1994 Mar 15;199(2):818-25.
RN [2]
RM 7881821
RT The large subunit of the pig heart mitochondrial membrane-bound beta-oxidation complex is a long-chain enoyl-CoA hydratase: 3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme.
RA Yang SY.
RL Comp Biochem Physiol B Biochem Mol Biol. 1994 Dec;109(4):557-66.
RN [3]
RM 8253773
RT Molecular cloning of the cDNAs for the subunits of rat mitochondrial fatty acid beta-oxidation multienzyme complex. Structural and functional relationships to other mitochondrial and peroxisomal beta-oxidation enzymes.
RA Kamijo T, Aoyama T, Miyazaki J, Hashimoto T.
RL J Biol Chem. 1993 Dec 15;268(35):26452-60. |
