HMM Summary Page: TIGR02469

Functionprecorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit
Gene SymbolcbiT
Trusted Cutoff78.30
Domain Trusted Cutoff78.30
Noise Cutoff67.15
Domain Noise Cutoff67.15
Isology Typeequivalog_domain
EC Number2.1.1.132
HMM Length124
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryHeme, porphyrin, and cobalamin
Gene Ontology TermGO:0046025: precorrin-6Y C5,15-methyltransferase (decarboxylating) activity molecular_function
GO:0046140: corrin biosynthetic process biological_process
AuthorSelengut J
Entry DateFeb 9 2005 4:58PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL.
References DR HAMAP; MF_00786; 17 of 18
Genome PropertyGenProp0113: cobyrinic acid diamide biosynthesis, aerobic pathway (HMM)
GenProp0275: cobyrinic acid diamide biosynthesis, anaerobic pathway (HMM)