| Accession | TIGR02475 |
| Name | CobW |
| Function | cobalamin biosynthesis protein CobW |
| Gene Symbol | cobW |
| Trusted Cutoff | 332.10 |
| Domain Trusted Cutoff | 332.10 |
| Noise Cutoff | 255.35 |
| Domain Noise Cutoff | 255.35 |
| Isology Type | equivalog |
| HMM Length | 342 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Heme, porphyrin, and cobalamin |
| Gene Ontology Term | GO:0009236: cobalamin biosynthetic process biological_process |
| Author | Selengut J |
| Entry Date | Feb 16 2005 9:48AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | The family of proteins identified by this model is generally found proximal to the trimeric cobaltochelatase subunit CobN which is essential for vitamin B12 (cobalamin) biosynthesis [1].
The protein contains an P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems.
A broader CobW family is delineated by two PFAM models which identify the N- and C-terminal domains (PF02492 and PF07683). |
| References | RN [1]
RT Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes.
RA Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS.
RL J Biol Chem. 2003 Oct 17;278(42):41148-59. Epub 2003 Jul 17.
RM PMID: 12869542 |
| Genome Property | GenProp0113: cobyrinic acid diamide biosynthesis, aerobic pathway (HMM) |
