HMM Summary Page: TIGR02475

Functioncobalamin biosynthesis protein CobW
Gene SymbolcobW
Trusted Cutoff332.10
Domain Trusted Cutoff332.10
Noise Cutoff255.35
Domain Noise Cutoff255.35
Isology Typeequivalog
HMM Length342
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryHeme, porphyrin, and cobalamin
Gene Ontology TermGO:0009236: cobalamin biosynthetic process biological_process
AuthorSelengut J
Entry DateFeb 16 2005 9:48AM
Last ModifiedFeb 14 2011 3:27PM
CommentThe family of proteins identified by this model is generally found proximal to the trimeric cobaltochelatase subunit CobN which is essential for vitamin B12 (cobalamin) biosynthesis [1]. The protein contains an P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems. A broader CobW family is delineated by two PFAM models which identify the N- and C-terminal domains (PF02492 and PF07683).
ReferencesRN [1] RT Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes. RA Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS. RL J Biol Chem. 2003 Oct 17;278(42):41148-59. Epub 2003 Jul 17. RM PMID: 12869542
Genome PropertyGenProp0113: cobyrinic acid diamide biosynthesis, aerobic pathway (HMM)