HMM Summary Page: TIGR02482

Gene SymbolpfkA
Trusted Cutoff371.35
Domain Trusted Cutoff371.35
Noise Cutoff359.45
Domain Noise Cutoff359.45
Isology Typeequivalog
EC Number2.7.1.11
HMM Length301
Mainrole CategoryEnergy metabolism
Subrole CategoryGlycolysis/gluconeogenesis
Gene Ontology TermGO:0003872: 6-phosphofructokinase activity molecular_function
GO:0006096: glycolysis biological_process
AuthorRosovitz MJ, Haft DH
Entry DateFeb 23 2005 2:46PM
Last ModifiedFeb 14 2011 3:27PM
Comment6-phosphofructokinase (EC catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC
ReferencesRN [1] RM 8436141 RT Molecular cloning and nucleotide sequence of the gene for pyruvate kinase of Bacillus stearothermophilus and the production of the enzyme in Escherichia coli. Evidence that the genes for phosphofructokinase and pyruvate kinase constitute an operon. RA Sakai H, Ohta T. RL Eur J Biochem. 1993 Feb 1;211(3):851-9. RN [2] RM 1828763 RT Purification and properties of the phosphofructokinase from Lactobacillus bulgaricus. A non-allosteric analog of the enzyme from Escherichia coli. RA Le Bras G, Deville-Bonne D, Garel JR. RL Eur J Biochem. 1991 Jun 15;198(3):683-7. RN [3] RM 2953977 RT Mutations in the active site of Escherichia coli phosphofructokinase. RA Hellinga HW, Evans PR. RL Nature. 1987 Jun 4-10;327(6121):437-9. DR HAMAP; MF_00339; 153 of 182
Genome PropertyGenProp0694: glucose utilization as fructose-1,6-bisphosphate (HMM)