| Accession | TIGR02485 |
| Name | CobZ_N-term |
| Function | precorrin 3B synthase CobZ |
| Gene Symbol | cobZ |
| Trusted Cutoff | 372.55 |
| Domain Trusted Cutoff | 372.55 |
| Noise Cutoff | 180.55 |
| Domain Noise Cutoff | 180.55 |
| Isology Type | hypoth_equivalog |
| HMM Length | 437 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Heme, porphyrin, and cobalamin |
| Gene Ontology Term | GO:0009236: cobalamin biosynthetic process biological_process |
| Author | Selengut J |
| Entry Date | Feb 24 2005 8:21AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | CobZ is essential for cobalamin biosynthesis (by knockout of the R. capsulatus gene [1]) and is complemented by the characterized precorrin 3B synthase CobG. The enzyme has been shown to contain flavin, heme and Fe-S cluster cofactors and is believed to require dioxygen as a substrate. This model identifies the N-terminal portion of the R. capsulatus gene which, in other species exists as a separate protein. The C-terminal portion is homologous to the 2-component signal transduction system protein CitB (TIGR02484). |
| References | RN [1]
RM PMID: 15525640
RT Identification and characterization of a novel vitamin B12 (cobalamin) biosynthetic enzyme (CobZ) from Rhodobacter capsulatus, containing flavin, heme, and Fe-S cofactors.
RA McGoldrick HM, Roessner CA, Raux E, Lawrence AD, McLean KJ, Munro AW, Santabarbara S, Rigby SE, Heathcote P, Scott AI, Warren MJ.
RL J Biol Chem. 2005 Jan 14;280(2):1086-94. Epub 2004 Nov 03. |
| Genome Property | GenProp0113: cobyrinic acid diamide biosynthesis, aerobic pathway (HMM) |
