HMM Summary Page: TIGR02491

Functionanaerobic ribonucleoside-triphosphate reductase activating protein
Gene SymbolnrdG
Trusted Cutoff126.10
Domain Trusted Cutoff126.10
Noise Cutoff114.40
Domain Noise Cutoff114.40
Isology Typeequivalog
EC Number1.97.1.-
HMM Length154
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole Category2'-Deoxyribonucleotide metabolism
Gene Ontology TermGO:0005506: iron ion binding molecular_function
GO:0008998: ribonucleoside-triphosphate reductase activity molecular_function
GO:0009265: 2'-deoxyribonucleotide biosynthetic process biological_process
GO:0043365: [formate-C-acetyltransferase]-activating enzyme activity molecular_function
AuthorSelengut J
Entry DateFeb 25 2005 10:42AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme [1] is a member of the radical-SAM family (PF04055) and utilizes S-adenosyl methionine, an iron-sulfur cluster and a reductant (dihydroflavodoxin [2]) to produce a glycine-centered radical in the class III (anaerobic) ribonucleotide triphosphate reductase (NrdD, TIGR02487). The two components form an alpha-2/beta-2 heterodimer.
ReferencesRN [1] RM PMID: 11389585 RT Activation of class III ribonucleotide reductase from E. coli. The electron transfer from the iron-sulfur center to S-adenosylmethionine. RA Padovani D, Thomas F, Trautwein AX, Mulliez E, Fontecave M. RL Biochemistry. 2001 Jun 12;40(23):6713-9. RN [2] RM PMID: 11297442 RT Activation of class III ribonucleotide reductase by flavodoxin: a protein radical-driven electron transfer to the iron-sulfur center. RA Mulliez E, Padovani D, Atta M, Alcouffe C, Fontecave M. RL Biochemistry. 2001 Mar 27;40(12):3730-6.
Genome PropertyGenProp0291: class III (anaerobic) ribonucleotide reductase (HMM)