|Function||type III secretion chaperone SycN|
|Domain Trusted Cutoff||84.55|
|Domain Noise Cutoff||37.05|
|Mainrole Category||Protein fate|
|Subrole Category||Protein folding and stabilization|
|Entry Date||Mar 3 2005 3:24PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Members of this protein family are part of the machinery of bacterial type III secretion in a number of bacteria that target animal cells. In the well-studied system from Yersinia, a complex of this protein (SycN) and YscB (PF07329) acts as a chaperone for the export of YopN (PMID:10094626). YopN then acts to control effector protein secretion, in response to calcium levels, so that secretion occurs only after contact with the targeted eukaryotic cell.|
RT A complex composed of SycN and YscB functions as a specific chaperone for YopN in Yersinia pestis.
RA Day JB, Plano GV.
RL Mol Microbiol. 1998 Nov;30(4):777-88.|
|Genome Property||GenProp0052: type III secretion (HMM)|
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