| Accession | TIGR02503 |
| Name | type_III_SycN |
| Function | type III secretion chaperone SycN |
| Gene Symbol | sycN |
| Trusted Cutoff | 84.55 |
| Domain Trusted Cutoff | 84.55 |
| Noise Cutoff | 37.05 |
| Domain Noise Cutoff | 37.05 |
| Isology Type | equivalog |
| HMM Length | 120 |
| Mainrole Category | Protein fate |
| Subrole Category | Protein folding and stabilization |
| Author | Haft DH |
| Entry Date | Mar 3 2005 3:24PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are part of the machinery of bacterial type III secretion in a number of bacteria that target animal cells. In the well-studied system from Yersinia, a complex of this protein (SycN) and YscB (PF07329) acts as a chaperone for the export of YopN (PMID:10094626). YopN then acts to control effector protein secretion, in response to calcium levels, so that secretion occurs only after contact with the targeted eukaryotic cell. |
| References | RN [1]
RM 10094626
RT A complex composed of SycN and YscB functions as a specific chaperone for YopN in Yersinia pestis.
RA Day JB, Plano GV.
RL Mol Microbiol. 1998 Nov;30(4):777-88. |
| Genome Property | GenProp0052: type III secretion (HMM) |
