|Domain Trusted Cutoff||365.25|
|Domain Noise Cutoff||214.40|
|Entry Date||Apr 5 2005 11:58AM|
|Last Modified||Jan 9 2012 11:52AM|
|Comment||Aminoacylation of tRNA(Cys) with Cys, and cysteine biosynthesis in the process, happens in Methanocaldococcus jannaschii and several other archaea by misacylation of tRNA(Cys) with O-phosphoserine (Sep), followed by modification of the phosphoserine to cysteine. In some species, direct tRNA-cys aminoacylation also occurs but this pathway is required for Cys biosynthesis. Members of this protein catalyze the second step in this two step pathway, using pyridoxal phosphate and a sulfur donor to synthesize Cys from Sep while attached to the tRNA.|
RT RNA-dependent cysteine biosynthesis in archaea.
RA Sauerwald A, Zhu W, Major TA, Roy H, Palioura S, Jahn D, Whitman WB, Yates JR 3rd, Ibba M, Soll D.
RL Science. 2005 Mar 25;307(5717):1969-72.
DR HAMAP; MF_01675; 25 of 26|
|Genome Property||GenProp0304: cysteine biosynthesis, tRNA-dependent (HMM)|
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