| Accession | TIGR02614 |
| Name | ftsW |
| Function | cell division protein FtsW |
| Gene Symbol | ftsW |
| Trusted Cutoff | 337.50 |
| Domain Trusted Cutoff | 337.50 |
| Noise Cutoff | 314.70 |
| Domain Noise Cutoff | 314.70 |
| Isology Type | equivalog |
| HMM Length | 357 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of murein sacculus and peptidoglycan |
| Gene Ontology Term | GO:0003674: molecular_function molecular_function |
| | GO:0009252: peptidoglycan biosynthetic process biological_process |
| | GO:0016021: integral to membrane cellular_component |
| | GO:0051301: cell division biological_process |
| Author | Haft DH |
| Entry Date | Jul 1 2005 10:19AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This family consists of FtsW, an integral membrane protein with ten transmembrane segments [1]. In general, it is one of two paralogs involved in peptidoglycan biosynthesis, the other being RodA, and is essential for cell division. All members of the seed alignment for this model are encoded in operons for the biosynthesis of UDP-N-acetylmuramoyl-pentapeptide, a precursor of murein (peptidoglycan). The FtsW designation is not used in endospore-forming bacterial (e.g. Bacillus subtilis), where the member of this family is designated SpoVE and three or more RodA/FtsW/SpoVE family paralogs are present. SpoVE acts in spore cortex formation and is dispensible for growth. Biological rolls for FtsW in cell division include recruitment of penicillin-binding protein 3 to the division site. |
| References | RN [1]
RM 15576787
RT Functional analysis of the cell division protein FtsW of Escherichia coli.
RA Pastoret S, Fraipont C, den Blaauwen T, Wolf B, Aarsman ME, Piette A, Thomas A, Brasseur R, Nguyen-Disteche M.
RL J Bacteriol. 2004 Dec;186(24):8370-9. |
