|Domain Trusted Cutoff||523.15|
|Domain Noise Cutoff||479.25|
|Mainrole Category||Energy metabolism|
|Gene Ontology Term||GO:0008912: lactaldehyde reductase activity molecular_function|
|Entry Date||Aug 1 2005 2:09PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This clade of genes encoding iron-containing alcohol dehydrogenase (PF00465) proteins is generally found in apparent operons for the catabolism of rhamnose or fucose. Catabolism of both of these monosaccharides results in lactaldehyde which is reduced by this enzyme to 1,2 propanediol . This protein is alternatively known by the name 1,2 propanediol oxidoreductase. This enzyme is active under anaerobic conditions in E. coli while being inactivated by reactive oxygen species under aerobic conditions . Under aerobic conditions the lactaldehyde product of rhamnose and fucose catabolism is believed to be oxidized to lactate by a separate enzyme, lactaldehyde dehydrogenase.|
RM PMID: 3275622
RT Metabolism of L-fucose and L-rhamnose in Escherichia coli: aerobic-anaerobic regulation of L-lactaldehyde dissimilation.
RA Baldoma L, Aguilar J.
RL J Bacteriol. 1988 Jan;170(1):416-21.
RM PMID: 2203757
RT Oxygen regulation of L-1,2-propanediol oxidoreductase activity in Escherichia coli.
RA Cabiscol E, Hidalgo E, Badia J, Baldoma L, Ros J, Aguilar J.
RL J Bacteriol. 1990 Sep;172(9):5514-5.|
|Genome Property||GenProp0457: rhamnose catabolism (NOCLUST)|
| ||GenProp0458: fucose catabolism (NOCLUST)|
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