HMM Summary Page: TIGR02638

Functionlactaldehyde reductase
Gene SymbolfucO
Trusted Cutoff523.15
Domain Trusted Cutoff523.15
Noise Cutoff479.25
Domain Noise Cutoff479.25
Isology Typeequivalog
EC Number1.1.1.77
HMM Length379
Mainrole CategoryEnergy metabolism
Subrole CategorySugars
Gene Ontology TermGO:0008912: lactaldehyde reductase activity molecular_function
AuthorSelengut J
Entry DateAug 1 2005 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis clade of genes encoding iron-containing alcohol dehydrogenase (PF00465) proteins is generally found in apparent operons for the catabolism of rhamnose or fucose. Catabolism of both of these monosaccharides results in lactaldehyde which is reduced by this enzyme to 1,2 propanediol [1]. This protein is alternatively known by the name 1,2 propanediol oxidoreductase. This enzyme is active under anaerobic conditions in E. coli while being inactivated by reactive oxygen species under aerobic conditions [2]. Under aerobic conditions the lactaldehyde product of rhamnose and fucose catabolism is believed to be oxidized to lactate by a separate enzyme, lactaldehyde dehydrogenase.
ReferencesRN [1] RM PMID: 3275622 RT Metabolism of L-fucose and L-rhamnose in Escherichia coli: aerobic-anaerobic regulation of L-lactaldehyde dissimilation. RA Baldoma L, Aguilar J. RL J Bacteriol. 1988 Jan;170(1):416-21. RN [2] RM PMID: 2203757 RT Oxygen regulation of L-1,2-propanediol oxidoreductase activity in Escherichia coli. RA Cabiscol E, Hidalgo E, Badia J, Baldoma L, Ros J, Aguilar J. RL J Bacteriol. 1990 Sep;172(9):5514-5.
Genome PropertyGenProp0457: rhamnose catabolism (NOCLUST)
GenProp0458: fucose catabolism (NOCLUST)