Accession | TIGR02643 |
Name | T_phosphoryl |
Function | thymidine phosphorylase |
Gene Symbol | deoA |
Trusted Cutoff | 570.70 |
Domain Trusted Cutoff | 570.70 |
Noise Cutoff | 471.85 |
Domain Noise Cutoff | 471.85 |
Isology Type | equivalog |
EC Number | 2.4.2.4 |
HMM Length | 437 |
Mainrole Category | Purines, pyrimidines, nucleosides, and nucleotides |
Subrole Category | Other |
Gene Ontology Term | GO:0006139: nucleobase-containing compound metabolic process biological_process |
| GO:0009032: thymidine phosphorylase activity molecular_function |
Author | Haft DH |
Entry Date | Aug 18 2005 11:12AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Thymidine phosphorylase (alternate name: pyrimidine phosphorylase), EC 2.4.2.4, is the designation for the enzyme of E. coli and other Proteobacteria involved in (deoxy)nucleotide degradation. It often occurs in an operon with a deoxyribose-phosphate aldolase, phosphopentomutase and a purine nucleoside phosphorylase. In many other lineages, the corresponding enzyme is designated pyrimidine-nucleoside phosphorylase (EC 2.4.2.2); the naming convention imposed by this model represents standard literature practice. |
References | RN [1]
RM 1322661
RT Substrate specificity of Escherichia coli thymidine phosphorylase for pyrimidine nucleosides with anti-human immunodeficiency virus activity.
RA Schinazi RF, Peck A, Sommadossi JP.
RL Biochem Pharmacol. 1992 Jul 22;44(2):199-204.
DR HAMAP; MF_01628; 65 of 67 |
Genome Property | GenProp0461: utilization of deoxynucleosides (HMM) |