|Domain Trusted Cutoff||570.70|
|Domain Noise Cutoff||471.85|
|Mainrole Category||Purines, pyrimidines, nucleosides, and nucleotides|
|Gene Ontology Term||GO:0006139: nucleobase-containing compound metabolic process biological_process|
| ||GO:0009032: thymidine phosphorylase activity molecular_function|
|Entry Date||Aug 18 2005 11:12AM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Thymidine phosphorylase (alternate name: pyrimidine phosphorylase), EC 184.108.40.206, is the designation for the enzyme of E. coli and other Proteobacteria involved in (deoxy)nucleotide degradation. It often occurs in an operon with a deoxyribose-phosphate aldolase, phosphopentomutase and a purine nucleoside phosphorylase. In many other lineages, the corresponding enzyme is designated pyrimidine-nucleoside phosphorylase (EC 220.127.116.11); the naming convention imposed by this model represents standard literature practice.|
RT Substrate specificity of Escherichia coli thymidine phosphorylase for pyrimidine nucleosides with anti-human immunodeficiency virus activity.
RA Schinazi RF, Peck A, Sommadossi JP.
RL Biochem Pharmacol. 1992 Jul 22;44(2):199-204.
DR HAMAP; MF_01628; 65 of 67|
|Genome Property||GenProp0461: utilization of deoxynucleosides (HMM)|
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