HMM Summary Page: TIGR02643

Functionthymidine phosphorylase
Gene SymboldeoA
Trusted Cutoff570.70
Domain Trusted Cutoff570.70
Noise Cutoff471.85
Domain Noise Cutoff471.85
Isology Typeequivalog
EC Number2.4.2.4
HMM Length437
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryOther
Gene Ontology TermGO:0006139: nucleobase-containing compound metabolic process biological_process
GO:0009032: thymidine phosphorylase activity molecular_function
AuthorHaft DH
Entry DateAug 18 2005 11:12AM
Last ModifiedFeb 14 2011 3:27PM
CommentThymidine phosphorylase (alternate name: pyrimidine phosphorylase), EC, is the designation for the enzyme of E. coli and other Proteobacteria involved in (deoxy)nucleotide degradation. It often occurs in an operon with a deoxyribose-phosphate aldolase, phosphopentomutase and a purine nucleoside phosphorylase. In many other lineages, the corresponding enzyme is designated pyrimidine-nucleoside phosphorylase (EC; the naming convention imposed by this model represents standard literature practice.
ReferencesRN [1] RM 1322661 RT Substrate specificity of Escherichia coli thymidine phosphorylase for pyrimidine nucleosides with anti-human immunodeficiency virus activity. RA Schinazi RF, Peck A, Sommadossi JP. RL Biochem Pharmacol. 1992 Jul 22;44(2):199-204. DR HAMAP; MF_01628; 65 of 67
Genome PropertyGenProp0461: utilization of deoxynucleosides (HMM)