HMM Summary Page: TIGR02655

Functioncircadian clock protein KaiC
Gene SymbolkaiC
Trusted Cutoff546.25
Domain Trusted Cutoff546.25
Noise Cutoff364.05
Domain Noise Cutoff364.05
Isology Typeequivalog
EC Number2.7.11.1
HMM Length484
Mainrole CategoryCellular processes
Subrole CategoryOther
Gene Ontology TermGO:0004674: protein serine/threonine kinase activity molecular_function
GO:0007623: circadian rhythm biological_process
GO:0016564: transcription repressor activity molecular_function
GO:0046777: protein autophosphorylation biological_process
AuthorHaft DH
Entry DateSep 7 2005 12:42PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are the circadian clock protein KaiC, part of the kaiABC operon that controls circadian rhythm. It may be universal in Cyanobacteria. Each member has two copies of the KaiC domain (Pfam model PF06745), which is also found in other proteins. KaiC performs autophosphorylation and acts as its own transcriptional repressor.
ReferencesDR PFAM; PF06745; KaiC RN [1] RM 15347812 RT Role of KaiC phosphorylation in the circadian clock system of Synechococcus elongatus PCC 7942. RA Nishiwaki T, Satomi Y, Nakajima M, Lee C, Kiyohara R, Kageyama H, Kitayama Y, Temamoto M, Yamaguchi A, Hijikata A, Go M, Iwasaki H, Takao T, Kondo T. RL Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13927-32. DR HAMAP; MF_01836; 13 of 13
Genome PropertyGenProp0465: circadian clock system KaiABC (HMM)