HMM Summary Page: TIGR02659

Functionmethylamine dehydrogenase (amicyanin) light chain
Gene SymbolmauA
Trusted Cutoff196.85
Domain Trusted Cutoff196.85
Noise Cutoff85.80
Domain Noise Cutoff85.80
Isology Typeequivalog
EC Number1.4.9.1
HMM Length186
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
AuthorHaft DH
Entry DateSep 8 2005 11:12AM
Last ModifiedDec 12 2011 9:10PM
CommentThis family consists of the light chain of methylamine dehydrogenase light chain, a periplasmic enzyme. This subunit contains a tryptophan tryptophylquinone (TTQ) prothetic group derived from Trp-114 and Trp-165 of the precursor, numbered according to the sequence from Paracoccus denitrificans. The enzyme forms a complex with the type I blue copper protein amicyanin and cytochrome. Electron transfer procedes from TQQ to the copper and then to the heme group of the cytochrome.
ReferencesRN [1] RM 15734739 RT Active site aspartate residues are critical for tryptophan tryptophylquinone biogenesis in methylamine dehydrogenase. RA Jones LH, Pearson AR, Tang Y, Wilmot CM, Davidson VL. RL J Biol Chem. 2005 Apr 29;280(17):17392-6. DR PFAM; PF02975; Me-amine-dh_L
Genome PropertyGenProp0860: tryptophan tryptophylquinone modification of methylamine dehydrogenase (HMM)