HMM Summary Page: TIGR02685
Accession | TIGR02685 |
Name | pter_reduc_Leis |
Function | pteridine reductase |
Trusted Cutoff | 321.70 |
Domain Trusted Cutoff | 321.70 |
Noise Cutoff | 199.55 |
Domain Noise Cutoff | 199.55 |
Isology Type | equivalog |
EC Number | 1.5.1.33 |
HMM Length | 267 |
Author | Haft DH |
Entry Date | Nov 11 2005 9:00AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Pteridine reductase is an enzyme used by trypanosomatids (including Trypanosoma cruzi and Leishmania major) to obtain reduced pteridines by salvage rather than biosynthetic pathways. Enzymes in T. cruzi described as pteridine reductase 1 (PTR1) and pteridine reductase 2 (PTR2) have different activity profiles. PTR1 is more active with with fully oxidized biopterin and folate than with reduced forms, while PTR2 reduces dihydrobiopterin and dihydrofolate but not oxidized pteridines. T. cruzi PTR1 and PTR2 are more similar to each other in sequence than either is to the pteridine reductase of Leishmania major, and all are included in this family. |
References | RM 16168672 RT Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor. RA Schormann N, Pal B, Senkovich O, Carson M, Howard A, Smith C, Delucas L, Chattopadhyay D. RL J Struct Biol. 2005 Oct;152(1):64-75. |