HMM Summary Page: TIGR02689

Functionarsenate reductase, glutathione/glutaredoxin type
Gene SymbolarsC
Trusted Cutoff157.60
Domain Trusted Cutoff157.60
Noise Cutoff113.80
Domain Noise Cutoff113.80
Isology Typeequivalog
EC Number1.20.4.1
HMM Length126
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
AuthorHaft DH
Entry DateNov 15 2005 11:45AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family represent a novel form of arsenate reductase, using glutathione and glutaredoxin rather than thioredoxin for reducing equivalents as do some homologous arsenate reductases. An example of this type is Synechocystis sp. strain PCC 6803 slr0946, and of latter type (excluded from this model) is Staphylococcus aureus plasmid pI258 ArsC. Both are among the subset of arsenate reductases that belong the the low-molecular-weight protein-tyrosine phosphatase superfamily.
ReferencesRM 14617642 RT An arsenate reductase from Synechocystis sp. strain PCC 6803 exhibits a novel combination of catalytic characteristics. RA Li R, Haile JD, Kennelly PJ. RL J Bacteriol. 2003 Dec;185(23):6780-9.
Genome PropertyGenProp0474: arsenical resistance system (HMM)