HMM Summary Page: TIGR02690

Functionarsenical resistance protein ArsH
Gene SymbolarsH
Trusted Cutoff292.25
Domain Trusted Cutoff292.25
Noise Cutoff138.10
Domain Noise Cutoff138.10
Isology Typeequivalog
HMM Length219
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0046685: response to arsenic-containing substance biological_process
AuthorHaft DH
Entry DateNov 15 2005 5:02PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family occur in arsenate resistance operons that include at least two different types of arsenate reductase. ArsH is not required for arsenate resistance in some systems. This family belongs to the larger family of NADPH-dependent FMN reductases (Pfam model PF03358). The function of ArsH is not known.
ReferencesRN [1] RM 10788346 RT The chromosomal arsenic resistance genes of Thiobacillus ferrooxidans have an unusual arrangement and confer increased arsenic and antimony resistance to Escherichia coli. RA Butcher BG, Deane SM, Rawlings DE. RL Appl Environ Microbiol. 2000 May;66(5):1826-33. RN [2] RM 14617642 RT An arsenate reductase from Synechocystis sp. strain PCC 6803 exhibits a novel combination of catalytic characteristics. RA Li R, Haile JD, Kennelly PJ. RL J Bacteriol. 2003 Dec;185(23):6780-9.
Genome PropertyGenProp0474: arsenical resistance system (HMM)