HMM Summary Page: TIGR02691

Functionarsenate reductase (thioredoxin)
Gene SymbolarsC
Trusted Cutoff174.30
Domain Trusted Cutoff174.30
Noise Cutoff112.10
Domain Noise Cutoff112.10
Isology Typeequivalog
EC Number1.20.4.-
HMM Length129
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0030612: arsenate reductase (thioredoxin) activity molecular_function
GO:0046685: response to arsenic-containing substance biological_process
AuthorHaft DH
Entry DateNov 16 2005 1:07PM
Last ModifiedDec 30 2011 10:08AM
CommentThis family describes the well-studied thioredoxin-dependent arsenate reductase of Staphylococcus aureaus plasmid pI258 and other mechanistically similar arsenate reductases. The mechanism involves an intramolecular disulfide bond cascade, and aligned members of this family have four absolutely conserved Cys residues. This group of arsenate reductases belongs to the low-molecular weight protein-tyrosine phosphatase family (PF01451), as does a group of glutathione/glutaredoxin type arsenate reductases (TIGR02689). At least two other, non-homologous groups of arsenate reductases involved in arsenical resistance are also known. This enzyme reduces arsenate to arsenite, which may be more toxic but which is more easily exported.
ReferencesDR PFAM; PF01451; LMWPc; Low molecular weight phosphotyrosine protein phosphatase RN [1] RM 12072565 RT All intermediates of the arsenate reductase mechanism, including an intramolecular dynamic disulfide cascade. RA Messens J, Martins JC, Van Belle K, Brosens E, Desmyter A, De Gieter M, Wieruszeski JM, Willem R, Wyns L, Zegers I. RL Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8506-11. DR HAMAP; MF_01624; 31 of 31
Genome PropertyGenProp0474: arsenical resistance system (HMM)