|Domain Trusted Cutoff||410.50|
|Domain Noise Cutoff||339.40|
|Mainrole Category||Energy metabolism|
|Gene Ontology Term||GO:0006113: fermentation biological_process|
| ||GO:0050182: phosphate butyryltransferase activity molecular_function|
|Entry Date||Nov 28 2005 12:52PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Members of this family are phosphate butyryltransferase, also called phosphotransbutyrylase. In general, this enzyme is found in butyrate-producing anaerobic bacteria, encoded next to the gene for butyrate kinase. Together, these two enzymes represent what may be the less common of two pathways for butyrate production from butyryl-CoA. The alternative is transfer of the CoA group to acetate by butyryl-CoA:acetate CoA transferase. Cutoffs for this model are set such that the homolog from Thermotoga maritima, whose activity on butyryl-CoA is only 30 % of its activity with acetyl-CoA, scores in the zone between trusted and noice cutoffs.|
|References||DR PFAM; PF01515; PTA_PTB; Phosphate acetyl/butyryl transferase
RT Restricted distribution of the butyrate kinase pathway among butyrate-producing bacteria from the human colon.
RA Louis P, Duncan SH, McCrae SI, Millar J, Jackson MS, Flint HJ.
RL J Bacteriol. 2004 Apr;186(7):2099-106.
RT Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima.
RA Bock AK, Glasemacher J, Schmidt R, Schonheit P.
RL J Bacteriol. 1999 Mar;181(6):1861-7.|
|Genome Property||GenProp0910: butyryl-CoA to butyrate, phosphotransbutyrylase pathway (HMM)|
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