| Accession | TIGR02738 |
| Name | TrbB |
| Function | type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB |
| Gene Symbol | trbB |
| Trusted Cutoff | 132.00 |
| Domain Trusted Cutoff | 132.00 |
| Noise Cutoff | 102.80 |
| Domain Noise Cutoff | 102.80 |
| Isology Type | equivalog |
| HMM Length | 153 |
| Author | Selengut J |
| Entry Date | Dec 17 2005 11:12AM |
| Last Modified | Nov 21 2011 3:46PM |
| Comment | This protein is part of a large group of proteins involved in conjugative transfer of plasmid DNA, specifically the F-type system. This protein has been predicted to contain a thioredoxin fold, contains a conserved pair of cysteines and has been shown to function as a thiol disulfide isomerase by complementation of an Ecoli DsbA defect [1]. The protein is believed to be involved in pilin assembly [2]. The protein is closely related to TraF (TIGR02739) which is somewhat longer, lacks the cysteine motif and is apparently not functional as a disulfide bond isomerase. |
| References | RN [1]
RM PMID: 16321931
RA Elton TC, Holland SJ, Frost LS, Hazes B.
RT F-like type IV secretion systems encode proteins with thioredoxin folds that are putative DsbC homologues.
RL J Bacteriol. 2005 Dec;187(24):8267-77.
RN [2]
RM PMID: 16138100
RA Frost LS, Leplae R, Summers AO, Toussaint A.
RT Mobile genetic elements: the agents of open source evolution.
RL Nat Rev Microbiol. 2005 Sep;3(9):722-32. |
| Genome Property | GenProp0484: F-type conjugation system (type IV secretion) specific components (HMM) |
