HMM Summary Page: TIGR02738

Functiontype-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB
Gene SymboltrbB
Trusted Cutoff132.00
Domain Trusted Cutoff132.00
Noise Cutoff102.80
Domain Noise Cutoff102.80
Isology Typeequivalog
HMM Length153
AuthorSelengut J
Entry DateDec 17 2005 11:12AM
Last ModifiedNov 21 2011 3:46PM
CommentThis protein is part of a large group of proteins involved in conjugative transfer of plasmid DNA, specifically the F-type system. This protein has been predicted to contain a thioredoxin fold, contains a conserved pair of cysteines and has been shown to function as a thiol disulfide isomerase by complementation of an Ecoli DsbA defect [1]. The protein is believed to be involved in pilin assembly [2]. The protein is closely related to TraF (TIGR02739) which is somewhat longer, lacks the cysteine motif and is apparently not functional as a disulfide bond isomerase.
ReferencesRN [1] RM PMID: 16321931 RA Elton TC, Holland SJ, Frost LS, Hazes B. RT F-like type IV secretion systems encode proteins with thioredoxin folds that are putative DsbC homologues. RL J Bacteriol. 2005 Dec;187(24):8267-77. RN [2] RM PMID: 16138100 RA Frost LS, Leplae R, Summers AO, Toussaint A. RT Mobile genetic elements: the agents of open source evolution. RL Nat Rev Microbiol. 2005 Sep;3(9):722-32.
Genome PropertyGenProp0484: F-type conjugation system (type IV secretion) specific components (HMM)