|Function||type-F conjugative transfer system pilin assembly protein TraF|
|Domain Trusted Cutoff||204.60|
|Domain Noise Cutoff||183.65|
|Entry Date||Dec 18 2005 9:48AM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This protein is part of a large group of proteins involved in conjugative transfer of plasmid DNA, specifically the F-type system. This protein has been predicted to contain a thioredoxin fold and has been shown to be localized to the periplasm . Unlike the related protein TrbB (TIGR02738), TraF does not contain a conserved pair of cysteines and has been shown not to function as a thiol disulfide isomerase by complementation of an Ecoli DsbA defect . The protein is believed to be involved in pilin assembly . Even more closely related than TrbB is a clade of genes (TIGR02740) which do contain the CXXC motif, but it is unclear whether these genes are involved in type-F conjugation systems per se.|
RM PMID: 3042757
RA Wu JH, Kathir P, Ippen-Ihler K
RT The product of the F plasmid transfer operon gene, traF, is a periplasmic protein
RL J Bacteriol. 1988 Aug;170(8):3633-9.
RM PMID: 16321931
RA Elton TC, Holland SJ, Frost LS, Hazes B.
RT F-like type IV secretion systems encode proteins with thioredoxin folds that are putative DsbC homologues.
RL J Bacteriol. 2005 Dec;187(24):8267-77.
RM PMID: 16138100
RA Frost LS, Leplae R, Summers AO, Toussaint A.
RT Mobile genetic elements: the agents of open source evolution.
RL Nat Rev Microbiol. 2005 Sep;3(9):722-32.|
|Genome Property||GenProp0484: F-type conjugation system (type IV secretion) specific components (HMM)|
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