| Accession | TIGR02752 |
| Name | MenG_heptapren |
| Function | demethylmenaquinone methyltransferase |
| Gene Symbol | menG |
| Trusted Cutoff | 419.85 |
| Domain Trusted Cutoff | 419.85 |
| Noise Cutoff | 409.30 |
| Domain Noise Cutoff | 409.30 |
| Isology Type | equivalog |
| EC Number | 2.1.1.163 |
| HMM Length | 231 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Menaquinone and ubiquinone |
| Gene Ontology Term | GO:0008168: methyltransferase activity molecular_function |
| | GO:0009234: menaquinone biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Dec 21 2005 3:54PM |
| Last Modified | Dec 12 2011 10:34PM |
| Comment | MenG is a generic term for a methyltransferase that catalyzes the last step in menaquinone biosynthesis; the exact enzymatic activity differs for different MenG because the menaquinone differ in their prenoid side chains in different species. Members of this MenG protein family are 2-heptaprenyl-1,4-naphthoquinone methyltransferase, and are found together in operons with the two subunits of the heptaprenyl diphosphate synthase in Bacillus subtilis and related species. |
| References | RM 9139683
RT Identification of a novel gene cluster participating in menaquinone (vitamin K2) biosynthesis. Cloning and sequence determination of the 2-heptaprenyl-1,4-naphthoquinone methyltransferase gene of Bacillus stearothermophilus.
RA Koike-Takeshita A, Koyama T, Ogura K.
RL J Biol Chem. 1997 May 9;272(19):12380-3.
DR HAMAP; MF_01813; 19 of 275 |
