|Function||DNA polymerase LigD, ligase domain|
|Domain Trusted Cutoff||227.75|
|Domain Noise Cutoff||206.40|
|Entry Date||Jan 10 2006 1:41PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||DNA repair of double-stranded breaks by non-homologous end joining (NHEJ) is accomplished by a two-protein system that is present in a minority of prokaryotes. One component is the Ku protein (see TIGR02772), which binds DNA ends. The other is a DNA ligase, a protein that is a multidomain polypeptide in most of those bacteria that have NHEJ, a permuted polypeptide in Mycobacterium tuberculosis and a few other species, and the product of tandem genes in some other bacteria. This model represents the ligase domain.|
RT Essential constituents of the 3'-phosphoesterase domain of bacterial DNA ligase D, a nonhomologous end-joining enzyme.
RA Zhu H, Wang LK, Shuman S.
RL J Biol Chem. 2005 Oct 7;280(40):33707-15.|
|Genome Property||GenProp0492: nonhomologous end-joining, bacterial type (HMM)|
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