HMM Summary Page: TIGR02794

Functionprotein TolA
Gene SymboltolA
Trusted Cutoff59.45
Domain Trusted Cutoff59.45
Noise Cutoff48.35
Domain Noise Cutoff48.35
Isology Typeequivalog
HMM Length362
Mainrole CategoryTransport and binding proteins
Subrole CategoryOther
Gene Ontology TermGO:0005215: transporter activity molecular_function
GO:0006810: transport biological_process
GO:0009405: pathogenesis biological_process
GO:0031237: intrinsic to external side of plasma membrane, in periplasmic space cellular_component
AuthorHaft DH
Entry DateJan 19 2006 9:34AM
Last ModifiedFeb 14 2011 3:27PM
CommentTolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB.
Genome PropertyGenProp0542: Tol-Pal system (HMM)