HMM Summary Page: TIGR02819

Functionformaldehyde dehydrogenase, glutathione-independent
Gene SymbolfdhA
Trusted Cutoff636.95
Domain Trusted Cutoff636.95
Noise Cutoff425.15
Domain Noise Cutoff425.15
Isology Typeequivalog
EC Number1.2.1.46
HMM Length397
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryOne-carbon metabolism
Gene Ontology TermGO:0018467: formaldehyde dehydrogenase activity molecular_function
GO:0046292: formaldehyde metabolic process biological_process
AuthorHaft DH
Entry DateFeb 8 2006 5:17PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family represent a distinct clade within the larger family of zinc-dependent dehydrogenases of medium chain alcohols, a family that also includes the so-called glutathione-dependent formaldehyde dehydrogenase. Members of this protein family have a tightly bound NAD that can act as a true cofactor, rather than a cosubstrate in dehydrogenase reactions, in dismutase reactions for some aldehydes. The name given to this family, however, is formaldehyde dehydrogenase, glutathione-independent.